16 Oct shingrix vis
Pain, redness, and swelling at the injection site, muscle pain, tiredness, headache, shivering, fever, and upset stomach are all common side effects of SHINGRIX. Harpaz R, Ortega-Sanchez IR, Seward JF et al. When this virus becomes active again, it can cause herpes zoster, or shingles. Applies to zoster vaccine, inactivated: intramuscular suspension. ), Do not administer vaccine that has been mishandled or has not been stored at the recommended temperature.1 134, If there are concerns about mishandling, contact the manufacturer or state or local immunization or health departments for guidance on whether the vaccine is usable.134, Data not available regarding use of zoster vaccine recombinant in pregnant women.1 In animal studies, no evidence that the vaccine or the AS01B adjuvant component of the vaccine affects fetal development or causes fetal harm.1, ACIP states consider deferring administration of zoster vaccine recombinant in pregnant women.4, Not known whether zoster vaccine recombinant vaccine is distributed into milk, affects milk production, or affects the breast-fed infant.1, Consider benefits of breast-feeding and clinical importance of the vaccine to the woman along with potential adverse effects on the breast-fed child from the vaccine or the underlying maternal condition (i.e., susceptibility to reactivation of VZV infection).1, ACIP states that recombinant vaccines generally do not pose any unusual risks for women who are breast-feeding or their breast-fed infants.134 However, these experts state consider deferring administration of zoster vaccine recombinant in women who are breast-feeding.4, Safety and efficacy not established in pediatric patients.1 Not indicated for prevention of primary varicella infection (chickenpox).1, Safety and efficacy established only in adults ≥50 years of age, including geriatric adults.1, No clinically meaningful differences in efficacy among various age groups of adults ≥60 years of age or between those ≥60 years of age and those 50–59 years of age;1 adverse effects reported less frequently in vaccine recipients ≥70 years of age compared with those 50–69 years of age.1, Injection site reactions (pain,1 2 3 4 erythema,1 2 4 swelling),1 2 4 myalgia,1 2 4 fatigue,1 2 3 4 headache,1 2 4 shivering,1 2 4 fever,1 2 4 GI symptoms (nausea, vomiting, diarrhea, abdominal pain).1 2 4, Concurrent administration with other age-appropriate vaccines or toxoids during the same health-care visit (using separate syringes and different injection sites) not expected to affect immunologic responses or adverse reactions to any of the vaccines.4, Immunosuppressive agents (e.g., corticosteroids), Potential for decreased immune responses to zoster vaccine recombinant1, Corticosteroids: Zoster vaccine recombinant may be used in those receiving low-dose systemic corticosteroid therapy (prednisone or equivalent in a dosage <20 mg daily) or inhaled or topical corticosteroid therapy;4 not evaluated in those receiving high-dose corticosteroid therapy4, Parenteral non-adjuvant-containing influenza virus vaccine inactivated: Concurrent administration of inactivated influenza vaccine (Fluarix Quadrivalent) and zoster vaccine recombinant in adults ≥50 years of age did not interfere with immune responses to either vaccine and was not associated with any safety concerns1 4, Adjuvant-containing influenza virus vaccine inactivated (Fluad): Safety and efficacy of concurrent or sequential administration with zoster vaccine recombinant not evaluated4, Parenteral non-adjuvant-containing influenza virus vaccine inactivated: May be given concurrently with zoster vaccine recombinant (using separate syringes and different injection sites)1 4, Pneumococcal 23-valent vaccine (PPSV23; Pneumovax 23): Concurrent administration with zoster vaccine recombinant in adults ≥50 years of age did not interfere with immune responses to either vaccine and did not affect safety profile of the vaccines10, Zoster vaccine recombinant has been administered to adults who received zoster vaccine live ≥5 years earlier;4 no data and no theoretical concerns indicating that zoster vaccine recombinant would be less effective or less safe if administered in adults who received zoster vaccine live <5 years earlier4, If used in adults who previously received zoster vaccine live, ACIP recommends that zoster vaccine recombinant be given ≥2 months after zoster vaccine live4 200, Vials containing lyophilized gE antigen: 2–8°; protect from light.1 Do not freeze; if freezing occurs, discard.1, Vials containing AS01B adjuvant suspension: 2–8°; protect from light.1 Do not freeze; if freezing occurs, discard.1, Use immediately following reconstitution.1 Alternatively, reconstituted vaccine may be stored at 2–8°C for ≤6 hours;1 discard if not used within 6 hours.1 Do not freeze: if freezing occurs, discard reconstituted vaccine.1, Zoster vaccine recombinant is an inactivated (recombinant) vaccine used to boost immunity to VZV, thereby reducing the risk of reactivation of VZV and development of zoster and complications of the disease.1, Commercially available as a kit containing single-dose vials of lyophilized VZV gE antigen and single-dose vials of AS01B adjuvant suspension.1 The VZV gE antigen component and the adjuvant component must be combined prior to administration (see Reconstitution under Dosage and Administration).1, The recombinant VZV gE antigen component is prepared using recombinant DNA technology and Chinese hamster ovary (CHO) cells.1 The adjuvant component is a liposomal formulation of AS01B that enhances the immune response to the recombinant VZV gE antigen.9, Administration of a 2-dose vaccination series of zoster vaccine recombinant in adults ≥50 years of age boosts VZV-specific cell-mediated immune responses and VZV-specific humoral immunity resulting in a reduced risk of zoster and PHN in vaccinees.1 2 3 4 9 19 The immunologic response to a 2-dose regimen of the vaccine has been evaluated in adults ≥50 years of age with and without a history of zoster.2 3 5 9, Herpes zoster (zoster, shingles) and varicella (chickenpox) are distinct clinical entities caused by the same virus, VZV.4 6 7 13 16 166 During primary infection, VZV causes chickenpox; the virus invades sensory neurons and becomes latent in sensory nerve ganglia, establishing a source of potential secondary infection.2 3 6 7 13 15 16 166, Zoster is characterized by unilateral, painful, vesicular cutaneous eruption with a dermatomal distribution.2 6 13 15 16 Pain may occur during the prodrome, the acute eruptive phase, and the postherpetic phase of the infection (PHN).6 13 16 Serious complications of the disease (e.g., scarring, bacterial superinfection, allodynia, cranial and motor neuron palsies, pneumonia, encephalitis, visual impairment, hearing loss, death) may occur.6 13 15 16, Minimum immune response that correlates with protection against zoster not established.1, Prior to administration, provide a copy of the appropriate CDC Vaccine Information Statement (VIS) to the patient or patient’s legal representative (VISs are available at [Web]).18, Advise patient of the risks and benefits of vaccination with zoster vaccine recombinant.1, Advise patient of the importance of receiving 2 doses of zoster vaccine recombinant given 2–6 months apart.1, Advise patient that zoster vaccine recombinant may not provide protection in all vaccinees.1, Inform patients about the potential for adverse reactions temporally associated with the vaccine.1 Clinicians or individuals can report any adverse reactions that occur following vaccination to the Vaccine Adverse Event Reporting System (VAERS) at 800-822-7967 or [Web].1, Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, and any concomitant illnesses.1, Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.1, Importance of informing patients of other important precautionary information.1 (See Cautions.). Vaccination with SHINGRIX may not protect all individuals; Ask your healthcare provider about the risks and benefits of SHINGRIX. Your health care provider can give you more information. Research Triangle Park, NC; 2017 Oct. 2. people icon. SHINGRIX is the first FDA‑approved shingles vaccine in over 10 years. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. https://www.cdc.gov/vaccines/hcp/vis/vis-statements/shingles.html Logs, Top
After you have chickenpox, the virus stays in your body and can cause shingles later in life. You will be subject to the destination website's privacy policy when you follow the link. Recommendations for the management of herpes zoster. Accessed 2018 Aug 15. Note: This document contains side effect information about zoster vaccine, inactivated. To learn more about shingles and protection with SHINGRIX, sign up for more information. Dworkin RH, Johnson RW, Breuer J et al. Shingrix is a vaccine used for the prevention of shingles in adults. (Shingrix) VIS October 30, 2019 CDC states that it is acceptable to use out-of-date VIS translations since there have not been significant content changes compared with the previous VIS. SHINGRIX is a 2-dose vaccine series (0.5 mL each) administered as an injection into the muscle in the upper arm. 1.
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