16 Oct joe thornton uchicago
2005 Feb 11; 120(3):343-55.
View in: PubMed, Thornton JW, Carroll SM. We employ a synthesis of evolutionary and phylogenetic techniques with functional molecular biology and biochemistry.
PLoS One. (2007 Sep) Nat Rev Genet. Epub 2010 Apr 5. Ancient mechanisms for the evolution of the bicoid homeodomain's function in fly development.
When not at the bench, Lora is a voracious reader, an aspiring chef, and a lover of hiking and biking outdoors. View in: PubMed, Harms MJ, Eick GN, Goswami D, Colucci JK, Griffin PR, Ortlund EA, Thornton JW. Now: Assistant Professor, University of Washington, Bothell. View in: PubMed, Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, MacKay JA, Juzumiene D, Bynum JM, Madauss K, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, Thornton JW, Fletterick RJ, Willson TM, Ingraham HA. 2014 Nov; 12(11):e1001994. Mol Biol Evol. Molly is now a Master’s student in biology with Sarah Cohen at SFSU, where she is working on the evolutionary response of fish populations to chemical contamination. (2016 Jan) Elife. Epub 2014 Jun 15. Der Center begann seine Profikarriere bei den Boston Bruins, die ihn im NHL Entry Draft 1997 an erster Position ausgewählt hatten. View in: PubMed, Cheng S, Park Y, Kurleto JD, Jeon M, Zinn K, Thornton JW, Özkan E. Family of neural wiring receptors in bilaterians defined by phylogenetic, biochemical, and structural evidence. All of these questions depend upon the map that relates changes in gene sequence to changes in gene function and, ultimately, in phenotype.
2016 Jan 12; 113(2):326-31. Jamie served as the anchor of the Eugene lab. (2003 Sep) Science. Joseph Joe Eric Thornton (* 2. View in: PubMed, Hart KM, Harms MJ, Schmidt BH, Elya C, Thornton JW, Marqusee S. Thermodynamic system drift in protein evolution. Bridgham JT, Carroll SM, Thornton JW (2013 Jul) Proc Natl Acad Sci U S A.
To address this question, Brian is applying techniques from protein engineering — experimental evolution and deep mutational scanning — to trace pathways from reconstructed ancient proteins to towards their modern functions. Author Correction: Origin of complexity in haemoglobin evolution.
Websites . 2009 Sep 24;461(7263):515-9. doi: 10.1038/nature08249.19779450, Crystal structure of an ancient protein: evolution by conformational epistasis. 2014 Sep 25; 159(1):58-68. Scientists use ‘molecular time travel’ to recreate evolution of complexity Jan 8, 2012. September 13, 2017. Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors.
Bryan is a computer scientist and phylogeneticist. Elife. 23166518 (Full Text), Evolution of increased complexity in a molecular machine.
Mo so thoroughly enjoyed having tiny flies buzzing around his head that he refuses to consider working with any other kind of organism. Vestigialization of an allosteric switch: genetic and structural mechanisms for the evolution of constitutive activity in a steroid hormone receptor.
View in: PubMed, Katsu Y, Cziko PA, Chandsawangbhuwana C, Thornton JW, Sato R, Oka K, Takei Y, Baker ME, Iguchi T. A second estrogen receptor from Japanese lamprey (Lethenteron japonicum) does not have activities for estrogen binding and transcription. (2010 Sep) Mol Biol Evol.
Mol Biol Evol.
He was previously on the faculty of the Institute for Ecology and Evolution and Department of Biology at the University of Oregon.
View in: PubMed, Anderson DP, Whitney DS, Hanson-Smith V, Woznica A, Campodonico-Burnett W, Volkman BF, King N, Thornton JW, Prehoda KE. Paul was an undergraduate and then a research assistant at the University of Illinois, where he studied antifreeze proteins in Antarctic notothenoid fishes. Epub 2012 Nov 15. 2009 Sep 24; 461(7263):515-9. John St. John was an undergraduate research assistant in the lab from 2007-2009.
Jesse completed his Ph.D in the MCB program at U. Colorado and is now a postdoc in microbiology at Oregon State.
Dave studied the evolution of DNA specificity in steroid receptors. 23864121(Full Text), Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors. 2017 02 08; 35(2):125-126. View in: PubMed, Kolaczkowski B, Thornton JW.
20413295 (Full Text), An epistatic ratchet constrains the direction of glucocorticoid receptor evolution. 2020 Jul; 583(7816):E26.
Mo did his undergraduate degree at the University of Indiana, where he worked with Kristi Montooth on evolutionary genetics in Drosophila.
Scientists engineer animals with ancient genes to test causes of evolution.
Luke was an undergraduate researcher in the lab from 2009-2010. University of Chicago. Evolution of steroid receptors from an estrogen-sensitive ancestral receptor. Anne was an undergraduate at the UO.
Harms MJ, Thornton JW View in: PubMed, Bridgham JT, Brown JE, Rodríguez-Marí A, Catchen JM, Thornton JW.
2000 Jun; 49(2):183-201. Nat Ecol Evol. Nature. Thornton JW, Need E, Crews D Bridgham JT, Ortlund EA, Thornton JW
Hormone-activated estrogen receptors in annelid invertebrates: implications for evolution and endocrine disruption. While in the lab, Justine won the UO Undergraduate Research Fellowship, and her Biology honors thesis work was published in PLOS Genetics. He worked on the development of a yeast system for directed evolution of ancestral steroid receptors and the expression and purification of resurrected glucocorticoid receptors. Origin of complexity in haemoglobin evolution.
She came to the lab because she was interested in endocrine disruption and public health. 2011 Jan 11; 108(2):E5; author reply E6.
She is studying how the corticosteroid synthesis pathway evolved in vertebrates.
2006 Aug; 147(8):3861-9.
As a senior scientist in the lab, you will conduct independent research, help to coordinate the lab’s operations, and work closely with students and… Continue Reading → 2017/03/29. (2004 Oct) Nature.
Joe Thornton wins 2019 Friend of Darwin award. Experimental test and refutation of a classic case of molecular adaptation in Drosophila melanogaster When she is not seeking a deep and systematic understanding of the evolutionary factors that have generated phenotypic diversity, Qinwen is enjoying the diverse cultures and nature of Chicago and the rest of the U.S. Paul is a multidisciplinary polar biologist. 15496922, Resurrecting ancient genes: experimental analysis of extinct molecules. 2004 May; 5(5):366-75. 2003 Sep 19;301(5640):1714-7. 2008 Jun; 25(6):1054-66. Epistasis in protein evolution.
Sean was a graduate student in the Biology Department and an NSF IGERT fellow. Justine’s goal is to apply evolutionary, molecular, and epidemiological approaches to address the AIDS pandemic in sub-Saharan Africa. 2012 Jun; 21(6):769-85. 2009 Apr; 150(4):1731-8. MA Siddiq, DW Loehlin, KL Montooth, JW ThorntonNature Ecology & Evolution 1: 0025, 2017. Mol Biol Evol. In choosing Thornton for this year's award, the NCSE said, "We note your important scholarly contributions in the area of gene and protein evolution, as well as your willingness to engage in the public discourse, especially to explain with clarity why intelligent design proponents cannot use your work to support their unscientific ideas. 2017 Jan 13; 1(2):25.
June is now completing her training at OSU’s School of Pharmacy. View in: PubMed, Starr TN, Thornton JW. Eick GN, Bridgham JT, Anderson DP, Harms MJ, Thornton JW View in: PubMed, Siddiq MA, Loehlin DW, Montooth KL, Thornton JW. Protein Sci.
26740169 (Full Text), Intermolecular epistasis shaped the function and evolution of an ancient transcription factor and its DNA binding sites.
After undergraduate training in biochemistry, Lora did her doctoral thesis at Johns Hopkins with Blake Hill, studying the biochemistry and structure of mitochondrial fission proteins.
View in: PubMed, Thornton JW. Crystal structure of an ancient protein: evolution by conformational epistasis.
Estrogen receptors in Xenopus: duplicate genes, splice variants, and tissue-specific expression. doi: 10.1371/journal.pgen.1003072. Proc Natl Acad Sci U S A. View in: PubMed, Finnigan GC, Hanson-Smith V, Stevens TH, Thornton JW. Experimental test and refutation of a classic case of molecular adaptation in Drosophila melanogaster.
Harms MJ, Thornton JW 20368266 (Full Text), Analyzing protein structure and function using ancestral gene reconstruction. View in: PubMed, Bridgham JT, Eick GN, Larroux C, Deshpande K, Harms MJ, Gauthier ME, Ortlund EA, Degnan BM, Thornton JW. 2019 05 14; 116(20):9837-9842. 2010 Oct 5;8(10). Resurrecting ancient genes: experimental analysis of extinct molecules.
He studies how the oligomeric architecture of proteins changes over evolutionary time and how oligomeric proteins evolve a high degree of specificity in their assemblies. Department of Ecology and Evolution. Thornton Lab website; Research Summary.
He graduated in August 2009 and is now a postdoc with Chris Marx at Harvard, where he is using experimental evolutionary approaches in bacteria to study molecular adaptation.
View in: PubMed, Thornton JW. Science. View in: PubMed, Harms MJ, Thornton JW. https://biosciences.uchicago.edu/after-uchicago/winter-2018-graduates Cell. Year; Resurrecting the ancestral steroid receptor: ancient origin of estrogen signaling.
We are characterizing receptor biodiversity across the animal kingdom, testing hypotheses about the functions of ancient proteins, and determining the specific mutations and changes in protein structure by which new receptor functions evolved hundreds of millions of years ago.
Historical contingency and its biophysical basis in glucocorticoid receptor evolution. View in: PubMed, Kolaczkowski B, Thornton JW. Science 301 (5640), 1714-1717, 2003.
Pervasive contingency and entrenchment in a billion years of Hsp90 evolution. Please let us know: Featuring current awardees helps students following in your footsteps to identify new funding opportunities. Articles Cited by. Victor studied the performance and accuracy of algorithms for phylogenetic inference and ancestral sequence reconstruction and played a lead role in our collaborative project reconstructing ancestral VTPases with Greg Finnigan and Tom Stevens. Chicago, IL 60637, Xiaochuan Pan and Charles Pelizzari, advisors, Kenneth Angielczyk and Zhe-Xi Luo, advisors, Biological Sciences Postdoctoral Affairs & Association | The University of Chicago. She helped pioneer the biochemistry side of the Thornton lab, revealing the mechanisms for the evolution of novel DNA-binding in the steroid receptors. Lamprey endocrinology is not ancestral.
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